“Then what about this?” Byron pointed at a rare antibiotic in her second plan. “Doxycycline. What does that have to do with neurological disease?”
Loyce’s mouth tilted slightly. “So you haven’t read the latest issue of ‘Pioneers of Neuroimmunology.’ A Harvard group published last year on how certain antibiotics modulate neuroinflammation.”
She pulled up a paper on her tablet. “Especially in post-mycoplasma autoimmune reactions like his.”
Byron took the tablet and skimmed the abstract. His expression turned complicated. He really hadn’t kept up, because it wasn’t his specialty.
“I… I need time to verify this,” he admitted, reluctantly.
“We don’t have time.” Loyce slid the tablet away. “Next patient.”
The second case was worse. Byron stared at the MRI—diffuse lesions scattered across the brain—and felt sweat bead on his forehead. “This looks like prion disease, but the symptoms don’t fully match…”
Loyce had already put on gloves and started examining the patient’s skin.
“Not prion.” She pointed to faint rashes on the arm. “See the telangiectasia? And this—” she gently lifted the eyelid, “microvascular changes on the conjunctiva.”
Byron leaned in. The abnormalities were there. “But what does that prove?”
“Vasculitis causing ischemic changes in the brain.” Loyce was already writing. “We need angiography to confirm, but it’s most likely a rare ANCA-associated subtype.”
“Wait!” Byron cut in. “If it’s vasculitis, why didn’t anyone catch it? The standard ANCA panel was negative!”

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